College football season is back with a full slate of games in Week 1, highlighted by the highly anticipated showdown between No. 1 Texas and No. 3 Ohio State, two programs with College Football Playoff Championship aspirations, and currently the two favorites for the National Championship at ESPN BET.
On Saturday evening on ABC, it's a ranked Tigers-on-Tigers clash between No. 9 LSU and No. 4 Clemson, and then on Sunday it's No. 6 Notre Dame on the road at No. 10 Miami.
Here are the available betting lines for all 22 Week 1 games featuring top-25 preseason ranked teams.
All times Eastern. For latest lines, go to ESPN BET
No. 25 Boise State -5.5 at South Florida
Thursday, 5:30 p.m., ESPN
Opening Line: Boise State -5.5, O/U 63.5
Money line: Boise State (-225); South Florida (+190)
Over/Under: 63.5 (O -105, U 115)
FPI Projection Boise State by 3.6 points, 65% probability to win game
Western Illinois at No. 12 Illinois -45.5
Friday, 7:30 p.m., Peacock
Opening Line: Illinois -45.5, O/U 63.5
Money line: Off
Over/Under: 63.5 (O -110, U 110)
FPI Projection Illinois by 40.4 points, >99% probability to win game
No. 1 Texas at No. 3 Ohio State -2.5
Saturday, Noon, FOX
Opening Line: Ohio State -2.5, O/U 47.5
Money line: Texas (+110); Ohio State (-130)
Over/Under: 47.5 (O -115, U 105)
FPI Projection Texas by 0.7 points, 53% probability to win game
Syracuse at No. 24 Tennessee -13.5
Saturday, Noon, ABC
Opening Line: Tennessee -13.5, O/U 50.5
Money line: Syracuse (+425); Tennessee (-650)
Over/Under: 50.5 (O -110, U 110)
FPI Projection Tennessee by 15.3 points, 89% probability to win game
Old Dominion at No. 20 Indiana -24
Saturday, 2:30 p.m., FS1
Opening Line: Indiana -24, O/U 54.5
Money line: Old Dominion (+1000); Indiana (-2000)
Over/Under: 54.5 (O -110, U -110)
FPI Projection Indiana by 15.3 points, 89% probability to win game
Nevada at No. 2 Penn State -44
Saturday, 3:30 p.m., CBS, Paramount+
Opening Line: Penn State -44, O/U 56.5
Money line: Off
Over/Under: 56.5 (O -115, U -105)
FPI Projection Penn State by 38.9 points, >99% probability to win game
Marshall at No. 5 Georgia -39.5
Saturday, 3:30 p.m., ESPN
Opening Line: Georgia -39.5, O/U 55.5
Money line: Off
Over/Under: 55.5 (O -115, U -105)
FPI Projection Georgia by 29.4 points, 97% probability to win game
No. 8 Alabama -13.5 at Florida State
Saturday, 3:30 p.m., ABC
Opening Line: Alabama -13.5, O/U 50.5
Money line: Alabama (-650); Florida State (+425)
Over/Under: 50.5 (O -110, U -110)
FPI Projection Alabama by 17.1 points, 91% probability to win game
South Dakota at No. 22 Iowa State -14.5
Saturday, 3:30 p.m., FOX
Opening Line: Iowa State -14.5, O/U 47.5
Money line: South Dakota (+500); Iowa State (-800)
Over/Under: 47.5 (O -110, U -110)
FPI Projection Iowa State by 18 points, 91% probability to win game
Montana State at No. 7 Oregon -29.5
Saturday, 4 p.m., BTN
Opening Line: Oregon -29.5, O/U 56.5
Money line: Montana State (+1800); Oregon (-6000)
Over/Under: 56.5 (O -110, U -110)
FPI Projection Oregon by 24.9 points, 95% probability to win game
Illinois State at No. 18 Oklahoma -35.5
Saturday, 6 p.m., ESPN+, SECN+
Opening Line: Oklahoma -35.5, O/U 60.5
Money line: Illinois State (+3000); Oklahoma (-20000)
Over/Under: 60.5 (O -110, U -110)
FPI Projection Oklahoma by 34.1 points, 98% probability to win game
Long Island University at No. 15 Florida
Saturday, 7 p.m., ESPN+, SECN+
No line posted
FPI Projection Florida by 51.9 points, >99% probability to win game
North Dakota at No. 17 Kansas State -25.5
Saturday, 7 p.m., ESPN+
Opening Line: Kansas State -25.5, O/U 55.5
Money line: North Dakota (+1200); Kansas State (-3000)
Over/Under: 55.5 (O -105, U -115)
FPI Projection Kansas State by 30.9 points, 98% probability to win game
UTSA at No. 19 Texas A&M -24.5
Saturday, 7 p.m., ESPN
Opening Line: Texas A&M -24.5, O/U 56.5
Money line: UTSA (+1500); Texas A&M (-5000)
Over/Under: 56.5 (O -110, U -110)
FPI Projection Texas A&M by 18.8 points, 92% probability to win game
No. 9 LSU at No. 4 Clemson -3.5
Saturday, 7:30 p.m., ABC
Opening Line: Clemson -3.5, O/U 57.5
Money line: LSU (+150); Clemson (-175)
Over/Under: 57.5 (O -110, U -110)
FPI Projection Clemson by 0.9 points, 54% probability to win game
New Mexico at No. 14 Michigan -34.5
Saturday, 7:30 p.m., NBC, Peacock
Opening Line: Michigan -34.5, O/U 49.5
Money line: Off
Over/Under: 49.5 (O -110, U -110)
FPI Projection Michigan by 30.4 points, 97% probability to win game
Arkansas-Pine Bluff at No. 23 Texas Tech
Saturday, 7:30 p.m., ESPN+
No line posted
FPI Projection Texas Tech by 52.9 points, 100% probability to win game
Georgia State at No. 21 Ole Miss -35.5
Saturday, 7:45 p.m., SEC Network
Opening Line: Ole Miss -35.5, O/U 60.5
Money line: Georgia State (+3500); Ole Miss (-50000)
Over/Under: 60.5 (O -110, U -110)
FPI Projection Ole Miss by 22.7 points, 94% probability to win game
East Texas A&M at No. 16 SMU
Saturday, 9 p.m., ACC Network
No line posted
FPI Projection SMU by 40.4 points, 99% probability to win game
Northern Arizona at No. 11 Arizona State -28.5
Saturday, 10 p.m., ESPN+
Opening Line: Arizona State -28.5, O/U 52.5
Money line: Off
Over/Under: 52.5 (O -110, U -110)
FPI Projection Arizona State by 31.4 points, 98% probability to win game
Virginia Tech at No. 13 South Carolina -8
Sunday, 3 p.m., ESPN
Opening Line: South Carolina -8, O/U 52.5
Money line: Virginia Tech (+250); South Carolina (-300)
Over/Under: 52.5 (O -105, U -115)
FPI Projection South Carolina by 5.6 points, 71% probability to win game
No. 6 Notre Dame -2.5 at No. 10 Miami
Sunday, 7:30 p.m., ABC
Opening Line: Notre Dame -2.5, O/U 49.5
Money line: Notre Dame (-130); Miami (+110)
Over/Under: 49.5 (O -105, U -115)
FPI Projection Notre Dame by 1.1 points, 55% probability to win game